Russia Claims 100% Success with Cancer Vaccine – But What’s the Truth?:-
Russia make a vaccine to fight cancer, it becomes a big thing in itself. It feels like a miracle because we have n’t been successful yet. But here you can see the news that is coming in the media that Russia’s entero-mix cancer vaccine shows 100% efficacy in early trials. So you will have to understand this a little bit. Look, everyone is continuously writing on social media that a vaccine to fight cancer has been made. But is Russia’s cancer vaccine ready for use? What is its actual truth ?
What Stage is the Vaccine Currently In?:-
Basically, in all the reports that were coming in the media, it was that the Russian scientists have announced a cancer vaccine named Enteromics, that a cancer vaccine has been made and here it was being reported in most of the media outlets that this vaccine shows 100% efficacy, which means you can understand that getting 100% success in the trial is a big thing in itself.
Is It an mRNA Vaccine or Something Else?:-
You never get to see it 100% normally. And here it was being claimed that this vaccine would be the world’s first mRNA based personalized cancer vaccine. And here it has been developed by this Russian agency, the Federal Medical and Biological Agency. Well, first understand what it actually means here.
Target Focus: What Kind of Cancer?:-
Look 100% Success it basically refers to early stage trials. Meaning, the preclinical one is not human also, meaning in the beginning you do trials on animals, so basically its trials are being ed about and what is it now, in 2025, this year itself, the trials are still going on on a small number of participants in humans, it is being that around 48, here, meaning for now you should understand that whatever evidence we have received has been through animal models, which are rats etc., the trials are done on mice.
What Does “100% Success” Actually Mean?:-
Some reports suggest that the phase one clinical trial has just begun. Meaning, the trial on humans has just begun. And it has no peer-reviewed publication yet. Because firstly, whatever you do inside your lab, you will it yourself, whether everything is good or bad, you will it yourself. But you have to get it reviewed by a third party. As far as peer review is concerned, nothing has happened yet. So it is most important for you to understand that saying 100% success will be a little wrong here. Basically two reports are coming out. Mostly if you look here it is that this vaccine is mRNA vaccine. Which again will you further. Then in some other places it is being that this is a virus based therapy. Ok? So there is confusion in this also whether this is a mix of both? What things are happening? See what happens is that the vaccine which is made from mRNA technology, most of the vaccines that you get now, like many of the Covid vaccines were made from mRNA technology.
What’s Still Needed to Call This a Breakthrough?:-
What happens in this is that a genetic instruction is delivered to the cells so that when it reaches the cells and the instruction that is given, then because of that the anti-tumor agents start getting produced and then your immune system learns from it so that it can recognize any cancer cells and attack them. So, the vaccines that are made like this are called mRNA based personalized vaccines. that’ll be. Then the second news that is coming is viral immunotherapy. Four types of non-pathogenic viruses have been used in this and the virus basically attacks your tumor cells directly. So you should understand the main difference that mRNA technology sends an instruction to your cells so that the antigens in your body, the tumor antigens, are produced. But what happens with this virus is that the non- pathogenic viruses are sent into your cells and what that virus does is it directly attacks the tumor cells. Due to which tumor fragments are released and because of that your immune activation takes place. So it is possible that some mix of both is being done in this way. That is what am ing you that initially such reports are coming here. But we will know exactly what is there here later. Well, here is a that many of you might be thinking that there are many types of cancer. So here, the vaccine that Russia has developed or is developing is currently under trial, so what is it focused on? Look, initially it is being that this vaccine is being focused on colorectal cancer. Colorectal is basically the colon cancer that occurs in the large intestine, so the main focus is on colon cancer. t is being that it will be developed in the future. Like for example, brain cancer , melanoma. So for other such cancers also, it will be developed here. But as was ing you that 100% success somewhere or the other becomes misleading. Why do you? 100% can mean anything like there were no adverse events in the subjects tested. Meaning he did not have any reaction, wrong. Ok? The side effects that occur. Apart from this, it can also mean that immune response was being generated in all the participants. This also means that tumor clearance was observed in animals. This means that your entire tumor has been removed. So 100% anything can happen. And that doesn’t mean it’s a 100% cure for humans. This is most important. Early fuzz or animal data, you can’t prove broadly human efficacy. Because many times it has been seen that even when 100% perfection is achieved in mice, those vaccines still fail in humans later on.
Why This Matters: Implications for Patients:-
And what’s more, this is just a very small sample. So sometimes, even from a small sample, the results appear wrong to us. We feel that everything is right and good. But when it goes into large samples, trials are conducted on 2000, 3000, 10000 people, then here you will get to see exactly what is its success rate. A good is that suppose we have to prove later that all this is correct. This vaccine is fine. So what things will be required for proof ? Before that, we will have to see the trial registry entries here. What does it mean that when this entire trial of the vaccine was going on, were the protocols followed or not? What things happened from where to where. Then peer reviewed publications are essential. The third party should review it to see if everything is fine or not. ndependent replication should occur in large groups.
Global Efforts in Cancer Vaccines:-
We will also have to look at the randomized control trials of Fuzz Two and Fuzz Three. Then regulatory approvals will have to be seen. t will be for regression review. So none of this has happened yet. So this means that there is just a lot of noise that the vaccine has been made. So this can prove to be a huge game changer. What will be its implication? What is happening to global patients is that the current treatment is very harsh. It has many side effects. You must have seen the treatments for cancer. How many problems there are. How severe are its side effects?
So somewhere we will move to the safer side from the harsh treatment here. So this is important. As far as India is concerned, it is obvious that if you look at it, colorectal and cervical cancer are the leading causes of cancer in India. Cancer mortality is the number of deaths due to cancer. So, if a personalized cancer vaccine is developed, it will transform everything.
Conclusion: Promising but Not Proven:-
But yes, many of you might have another in your mind that whether these are the only cancer vaccines that are being made. Look, it is not like that. Meaning, apart from Russia, other countries are also trying. This launch was done in collaboration with pharmaceutical company Biotech. And their goal was basically to speed up the clinical trials of mRNA personalized cancer vaccine so that it could be tested on people diagnosed with cancer. The US Food and Drugs Administration (FDA) has also approved a cancer vaccine here so far, you can see its name. So what’s happening here is that this approval was given in 2010 for prostate cancer. But keep in mind that this vaccine can also keep a patient alive for a maximum of six months extra. That’s all his survival is. He can extend his life. So we are still far behind in terms of cancer. The conclusion is that it represents the entero mix of Russia.It is going in a good direction. 100% success has not yet been proven in humans and has only been seen on a preclinical and small scale. So the bottom line is that it is promising but not a proven cure yet.